* They took the paper but not this cover
Illustration of the SLR-Seq protocol with application to transcriptome sequencing ("SLR-RNA-Seq"). Each of 100s of wells is represented by a cone. Each cone contains a limited number of molecules (1-2 are represented here in grey and red, although in reality 1000-2000 is more accurate).
Red molecules represent isoforms from one (fictional) gene, grey molecules represent isoforms from other genes. Red molecules have 3 or 5 exons (represented by oval shapes) and exons 2 and 4 are included/excluded from these molecules in a coordinated manner - an illustration of Distant
Molecularly Associated Pairs (dMAPs) of alternative exons - see Tilgner et al in this issue. Artwork by Luisa Lente, concept by Hagen Tilgner
Tilgner H*, Jahanbani F* et al. Comprehensive transcriptome analysis using synthetic long read sequencing reveals molecular co-association and conservation of distant splicing events. Nature Biotechnol. 2015 May 18. doi: 10.1038/nbt.3242. [Epub ahead of print]
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